Point Loma is a seaside community of San Diego, California. Geographically it is a hilly peninsula that is bordered on the west and south by the Pacific Ocean, the east by the San Diego Bay and Old Town and the north by the San Diego River. Along with the Coronado peninsula, Point Loma separates San Diego Bay from the Pacific Ocean.

Point Loma has an estimated population of 45,887 (including Ocean Beach), according to the 2000 Census. The 2008 population of the 92106 and 92107 ZIP codes is estimated at 48,285.

There are several distinct neighborhoods in the Point Loma peninsula. The commercial and retail heart of the peninsula is called Point Loma Village. Its retail establishments serve local residents as well as yachting and sport fishing interests. The streets in Point Loma Village are lined with hundreds of jacaranda trees as a result of community beautification efforts.

Connected to Point Loma Village by a causeway is Shelter Island, which is actually not an island but a former sandbank in San Diego Bay. Shelter Island was developed in the 1950s after it was built up into dry land using material dredged from the bay. It is under the control of the Port of San Diego and contains hotels, restaurants, marinas, and public parkland.

The newest commercial and retail area is found at Liberty Station, site of the former Naval Training Center San Diego, which also has residential and educational sections.

The Midway district at the northern end of the peninsula, adjacent to the San Diego River and the I-5 and I-8 freeways, is primarily commercial and industrial with a few small residential developments.

Most neighborhoods in Point Loma consist primarily of single family homes. The bayside residential area is called La Playa and lies somewhat north of the original La Playa, the beach where commercial and military ships anchored during the early days of the city. La Playa includes some of the most expensive homes in San Diego. Some bayfront homes have private piers for small boats.

The hills above La Playa are known as the Wooded Area on the bay side of Catalina Boulevard (so called because of the many mature trees in the area), and the College Area on the ocean side (because of the proximity of Point Loma Nazarene College). The Sunset Cliffs neighborhood is on the west side, above ocean bluffs, and is known for its views of the Pacific Ocean.

Roseville, named for San Diego pioneer Louis Rose, encompasses the oldest settled part of the peninsula. Many Portuguese fishermen and fishing boat owners settled here more than 100 years ago. Some people refer to the area as “Tunaville” because of its association with the tuna-fishing fleet. The hilly area above Roseville is known as Fleetridge, named for its developer David Fleet, a son of Reuben H. Fleet.

The bayside hills between Rosecrans Street and Chatsworth Boulevard are known as Loma Portal. A distinctive feature of this neighborhood is the location of street lights in the middle of street intersections instead of on the sidewalk. Loma Portal lies directly in the takeoff pattern for planes from Lindbergh Field, making it the home of the “Point Loma Pause” where all conversation ceases temporarily due to airplane noise. The streets in Loma Portal are known as the "alphabetical author streets". The streets are named for authors in alphabetical order from Addison to Zola, with a second partial cycle from Alcott to Lytton.

The northwest corner of the peninsula, where the San Diego River flows into the ocean, is a separate community known as Ocean Beach. The southern one-third of the Peninsula is entirely federal land, including Naval Base Point Loma, Fort Rosecrans National Cemetery, and Cabrillo National Monument.